ISGylation induction decreases MVB numbers and impairs exosome secretion. Using ISG15-knockout mice and mice expressing the enzymatically inactive form of the de-ISGylase USP18, we demonstrate in ...

However, ILVs also form in the absence of ESCRTs ... carry MHC-peptide complexes recognized by T lymphocytes. Secretion of those exosomes could promote antitumor immune responses.

High centrifugal force can damage exosome integrity Charge neutralization-based precipitation (commercial kits) 32,33 Based on the principle of compound polymerization precipitation. Samples are mixed ...

8 “Live reporters like these can reveal unexpected cellular behaviors by allowing real-time visualization of the secretion and interaction of exosomes with cells. Although we know exosomes are ...

A review led by Academician Yulong Yin from the Institute of Subtropical Agriculture of the Chinese Academy of Sciences has shed new light on the intricate interplay between exosomes and autophagy ...

Researchers have now identified a microRNA, miR-940, that is abundant in exosomes secreted by prostate cancer cells and can trigger bone-forming lesions in mice. The findings indicate that ...

"The phase-specific exosome secretion of LIFES meets physiological requirements, which aligns with the native multi-target and multi-stage paracrine regulation effects observed in physiological ...

A recent study even points to exosomes as a culprit for distributing amyloid-β, the plaque-forming protein that accumulates in the brains of people with Alzheimer’s disease. If exosomes can so ...

Basically, exosomes are like a cell’s text message—but instead of words or emojis, they contain data in the form of proteins, lipids, growth factors, and RNA. “In skincare, exosomes are ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...