Tumors contain a fraction of cancer stem cells that maintain the propagation of the disease. The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to be enriched leukemic ...

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Dana-Farber Cancer Institute researchers have identified factors that determine whether donor lymphocyte infusion (DLI), a standard therapy for patients with acute myeloid leukemia (AML ... T cells ...

BioSkryb Genomics, a Durham company focused on single-cell and ultra-low input multiomics, has introduced a new service called ResolveSEQ MRD, which allows more detailed classification and ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

Oct. 9, 2024 — Researchers have created a CRISPR-based rapid molecular diagnostic for two forms of leukemia that are driven by mutations that involve gene ... by which acute myeloid leukemia ...

Objective: Using bioinformatics analyses, this study aimed to identify lncRNAs related to the immune status of acute myeloid leukemia (AML ... AML-related miRNA expression microarray data, and gene ...

The Damon Runyon Cancer Research Foundation has announced eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, established to support high-risk, high-reward ideas with the potential to ...

The first patient with relapsed/refractory acute myeloid leukemia has received KJ-C2320 ... which eliminates the surface expression of TCR and human leukocyte antigen class I (HLA-I). This approach ...

For CRISPR-Cas9-mediated PHGDH knockout in MOLM-14 and U937 cells, single-guide RNAs (sgRNAs) were designed targeting both exon 6 and exon 2 of the PHGDH gene. Nucleofections ... inhibits leukemia ...

The European Leukemia Net (ELN) published their 2024 recommendations for the genetic risk classification of adult patients with acute myeloid leukemia ... compared with a 4-gene signature ...