Loop diuretics are used to treat volume overload ... They reach their site of action by binding to serum proteins, notably albumin, and are then actively secreted into the urine at the straight ...

Over time, the retention of sodium leads to crackles, peripheral edema, hepatomegaly with ascites, increased blood volume, and increased cardiac filling pressures. Although diuretics do not ...

They come in different types, including carbonic anhydrase inhibitors (CAIs), loop diuretics ... which are used to inhibit the action of an enzyme called carbonic anhydrase.