Figure 1: A photomicrograph of giant, detached, hypernucleated osteoclasts after long-term oral aminobisphosphonate therapy. Paget disease of bone, hyperparathyroidism, giant cell tumor and ...

25 Bisphosphonates are thus targeted cytotoxic drugs with an extraordinary specificity for osteoclasts ... bone resorption such as for Paget's disease of the bone and for bone metastases.

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, causing pain, fractures, and decreased quality of life. These conditions often ...

Lucía Chávez Gutiérrez (VIB-KU Leuven) has unraveled the genetic contributions to familial Alzheimer's Disease development and revealed how specific mutations act as a clock to predict the ...

Steve Christo-Corbis/Getty Images Wegovy (semaglutide) could offer a new option to treat severe liver disease based on new clinical trial evidence. The GLP-1 drug resolved liver inflammation in ...

These findings have implications for developing microbiome-based therapies to treat fatty liver disease. Metabolic dysfunction–associated fatty liver disease (MAFLD) is the most common chronic ...

GTA schools are reporting cases of a disease commonly known as “slapped cheek” syndrome — an infectious virus often appearing in school-age children. A recent letter posted on a door at a ...

Using semaglutide injections, scientists were able to reverse life-threatening cases of liver disease in a new clinical trial published in The New England Journal of Medicine. Semaglutide ...

Eating about a dozen servings of ultraprocessed food each day could more than double your risk of developing Parkinson’s disease, according to a new study. A single serving in the study was 8 ...

Lucía Chávez Gutiérrez (VIB-KU Leuven) have unraveled the genetic contributions to familial Alzheimer's Disease development and revealed how specific mutations act as a clock to predict the ...

More than 16,000 chemicals are used to produce plastics — and some are silently killing us. Particularly worrisome is di-2-ethylhexylphthalate, or DEHP, a chemical used to soften plastic products.