reveal the molecular mechanism of propofol addiction, explore the changes of hippocampal and intestinal flora in mice after propofol addiction, and provide therapeutic strategies for clinical ...

either by directly repurposing propofol or by designing new, more selective drugs that have the same mechanism of action," said study co-senior author Dr. Crina Nimigean, professor of physiology ...

either by directly repurposing propofol or by designing new, more selective drugs that have the same mechanism of action." Dr. Crina Nimigean, study co-senior author, professor of physiology and ...

Propofol is a drug that binds to GABA receptors in the brain, inhibiting neurons that have those receptors. Other anesthesia drugs act on different types of receptors, and the mechanism for how ...

using drug infusions of propofol and remifentanil. Our method employs long short-term memory (LSTM) and gate residual network (GRN) networks to improve the efficiency of feature fusion and applies an ...

The team then showed that propofol-induced transport delays led to a significant decrease of protein delivery to axons. "The mechanism by which propofol works is not fully understood," Bentley said.

4 Propofol. Propofol is a dose-dependent sedative-hypnotic with agonism of GABA receptors through a site different from that of benzodiazepines, and inhibition of NMDA subtype of glutamate receptor.

To test the above hypothesis, a series of in vitro and in vivo experiments were performed to investigate the effect and underlying mechanism of propofol on ferroptosis. This study demonstrates that ...

In the experiment, we investigated the chronotropic function of propofol and the underlying mechanism. Rabbits of both sexes were randomly divided into 4 groups: propofol 5 mg/kg group, 10 mg/kg group ...

However, in the late 20th century, it was the resilience of John B. Glen that led to the development of one of the most common anesthetics used nowadays: propofol. Glen, a veterinary surgeon, helped ...

In contrast, there was not an effect by propofol binding at the trailing head. These results provide a mechanism by which propofol disrupts kinesin stepping, which may diminish their ability to ...