TFEB and TFE3 are two key transcription factors that regulate lysosomal biogenesis. TFEB/TFE3 links autophagy and lysosomal biogenesis through the transcriptional activation of genes involved in ...

This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, China School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Key Laboratory of ...

the company wrote. Emergency as flooding affects homes Queensland Police issued an emergency declaration under the Public Safety Preservation Act (PSPA) for Adavale, a tiny rural town west of Roma ...

Queensland Police issued an emergency declaration under the Public Safety Preservation Act (PSPA) for Adavale, a tiny rural town west of Roma, about 8.15am on Thursday. “Emergency services have ...

Translocation renal cell carcinoma (tRCC) is a rare subtype of kidney cancer characterized by genetic translocation events frequently involving transcription factor TFE3 or more rarely TFEB. While the ...

CASM supports Lysosomal biogenesis through TFEB activation, where the inhibition of FLCN-FNIP1/2 via GABARAP enables TFEB nuclear translocation to drive lysosomal gene expression and stress response ...

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