Using the glucocorticoid receptor, a well known substrate for PP5, we demonstrate that SUMOylation results in substrate release from PP5. We harness this information to create a non-SUMOylatable K430R ...

Zhijian “James” Chen received this year’s Albert Lasker Award for discovering cGAS, an enzyme which scopes out DNA-based ...

Alfred explains that enzymes are proteins with specific shapes that can bind with substrates through their specific active site. Alfred also explains how temperature and pH can affect the enzyme’s ...

As advanced packaging technologies and large-size integrated substrate solutions become key development areas for technology ...

Scientists developed a new material that keeps essential features of the enzyme’s natural substrate. This new material is ...

Researchers want to transform the natural and abundant resource wood into useful materials, and central to that is a ...

A fungal enzyme (pink) can separate hemicellulose and lignin, but to do so, it needs to bind to a short chain of hemicellulose. Only by creating a test substrate that also has this short hemicellulose ...

Researchers want to transform the natural and abundant resource wood into useful materials, and central to that is a ...

Fungi have enzymes, tiny chemical machines, capable of doing that, but to improve and adapt them for industrial use, we need to understand how they work, and researchers did not have a suitable feed, ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Anthony Green's research group at the University of Manchester, UK, reengineers enzymes to have catalytic functions beyond ...

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