How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

I nside the human airway, a certain cell type reigns supreme: multiciliated cells, decorated with dozens of hair-like cilia all beating in tandem. These cells are responsible for clearing out foreign ...

The ability to sustain unscheduled proliferation is a hallmark of cancer. The normal process of cell division occurs via the cell cycle, a series of highly regulated steps that are orchestrated at the ...

All stages of the cell cycle in normal cells are tightly controlled. In cancer cells, several proteins and genes that impact the progression of the cell cycle are overexpressed or mutated and turn ...

The cell cycle is a complex process that involves the growth and division of a cell. It is divided into four phases: G1, S, G2, and M. During each phase, the cell undergoes a series of events that ...

Cancer, the scourge of the 20th century, is in its most basic form the uncontrolled proliferation of invasive cells as a consequence of perturbations in the genetic and biochemical processes of a ...

Hence, normal cell cycle progression is highly sensitive to regulation by flavin-containing oxidases, and DNA damage is not a necessary prerequisite for checkpoint control.

The level of TERT mRNA and active telomerase in most phases of cell cycle (G0/G1, G1/S, S) are above normal cells, while, cells arrested in G2/M phase exhibited almost the same level of normal cells.

When cells cycle fast, ... "When a normal cell that divides quickly meets MLL-AF9, this combination creates a monster cell that is stuck in a state of perpetual fast division," Guo said.

"Cancer can occur when the normal checkpoints in the cell cycle are misregulated somehow and the [unhealthy] cell starts dividing," Loros says. Usually, ...