The recurrence risk with trisomy is 1% to 2% or the maternal age risk, whichever is greater. [2] There is a recurrence risk of 5% to 10% for an affected live-born infant in cases when a parent has ...

Jerome Lejeune in France and Patricia Jacobs in the United States were able to identify a supernumerary copy of chromosome 21 in karyotypes prepared from DS patients (Figure 2). Trisomy 21 is now ...

Gene editing techniques may eventually allow trisomy to be treated at the cellular level, according to an in vitro proof-of-concept study. Down syndrome is caused by the presence of a third copy ...

This shows maternal-age-specific estimates of trisomy among all clinically recognized human pregnancies, generated by combining data from individual trisomies and assuming a spontaneous abortion ...