Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Amid a hospitality landscape in which many hotels have moved far beyond single-use plastics, how does the Populus in Denver measure up? By Cindy Hirschfeld Photographs by Andrew Miller One of the ...

“News Flash! Who back Zak!,” Townshend wrote on Instagram on Saturday. “Zak is not being asked to step down from The Who. There have been some communication issues, personal and private on ...

Here, we find that P27KIP1 degradation ... mediated ubiquitin-proteasome degradation of P27KIP1. On the other hand, hSPAR acts as a glutamine inhibitor and triggers the translocation of accumulated ...

Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3‐f) for ubiquitination and degradation by the proteasome ... chloroquine (an ...

Scientists design a process that merges metal extraction, alloying and processing into one single, eco-friendly step. Max Planck scientists design a process that merges metal extraction ...

A research team has now found a way to delay the degradation of the vitamin ... disorders and neurodegenerative diseases. In a next step, Gohla and her team now want to develop improved substances ...

Targeting USP7 to induce ubiquitination degradation of oncogenic ATAD2 and effects on cholangiocarcinoma growth. CR = complete response, PR = partial response, SD = stable disease, OR = objective ...

(1) Degradation of ... and degraded by the ubiquitin-proteasome system. (3) A portion of mitochondria budding off as mitochondria-derived vesicles and fuse with lysosomes for degradation.

and subsequent IRF1 ubiquitination and degradation. Consequently, loss of SPOP increased transcriptional output of IRF1-stimulated genes. The IRF1 protein is ubiquitinated and turned over by the ...

During the initial ubiquitination step ... of the proteasome (Nathan et al., 2013). Therefore, K63-linked polyubiquitin chains play various roles in non-degradative signaling processes or can also ...

Protein degradation is a highly co-ordinated ... It occurs in all cells in the body. The ubiquitination stamp allows the proteasome to recognize unwanted proteins and sort them for removal.