EGFRvIII-positive glioblastoma. Participants had to have measurable disease, defined as at least one lesion at least 10 mm in diameter on magnetic resonance imaging (MRI). Previous receipt of ...

MRI scanning, a form of brain imaging ... targets a molecule known as EGFRv3 and another form known as “wild” EGFR, which are found in glioblastoma. The “TEAM” refers to a “T-cell ...

A new study shows the potential power of imaging paired with radiation to shape treatment for glioblastoma patients in real time. The study, led by researchers at Sylvester Comprehensive Cancer ...

In the 57-year-old woman, an MRI taken five days after ... included six patients with recurrent glioblastoma. Their CAR-T cells also sought out EGFR, but used another protein, called IL13Rα2 ...

Glioblastoma Multiforme (Frontal Lobe). T1-weighted axial MRI. Note the large mass in the deep left frontal lobe with central necrosis and surrounding edema. Also note the prominent enhancement with ...

The first possibility is that CHCHD2 decreases the sensitivity of mutated EGFR to cytotoxic drugs. Patients with glioblastoma only survive for 15-20 months, despite being subjected to an arsenal ...

Researchers have long considered the epidermal growth factor receptor (EGFR), a protein that sits on the surface of cells, as a driver of this cancer, Dr. Habib explained. In nearly half of ...

While over half of GBM cases are driven by EGFR alterations and/or amplifications, there are no approved EGFR inhibitors for the treatment of GBM due to the lack of sufficient brain penetration to ...

ONCR-719 is a novel, armed oncolytic HSV-1 vector engineered with targeted entry via EGFR/EGFRvIII and expresses four immunomodulatory payloads designed to reverse GBM’s immunosuppressive tumor ...