Sep 17, 2024 · Synovial fluid analysis is helpful for determining the underlying cause of arthritis, particularly for septic or crystal-induced arthritis. The white cell count, differential count, cultures, Gram stain, and crystal search using polarized light microscopy are the most useful studies.

In the setting of noninfectious inflammatory arthritis, synovial fluid leukocyte counts may be >20,000 cells/microL (often termed "pseudoseptic"). In general, the higher the synovial fluid leukocyte count, the greater the concern for septic arthritis.

A needle is inserted into a joint for two main indications: aspiration of fluid (arthrocentesis, for diagnosis or relief of pressure) or injection of medications. In practical terms, most injections into joints consist of a glucocorticoid, a local anesthetic, or a combination of the two.

Extracted data included synovial fluid leukocyte count, Gram's stain, culture, past medical history, and discharge diagnosis. Fisher exact test was used to compare proportions. Sensitivity and means were calculated with 95% confidence intervals (CI).

- Guide to interpretation of synovial fluid analysis - Septic arthritis positive gram stain - Septic arthritis negative gram stain

In addition to a careful history and physical examination, arthrocentesis and synovial fluid analysis is often required in making a definitive diagnosis. The initial evaluation and differential diagnosis of an adult presenting with a single sore joint is presented here ( table 1 ).

Synovial fluid analysis — Synovial (joint) fluid is obtained under sterile conditions through a needle inserted into the affected joint. The fluid is then analyzed to determine if crystals or infection are present.

Oct 28, 2024 · Gout (monosodium urate [MSU] crystal deposition disease) is characterized biochemically by extracellular fluid urate saturation, which is reflected in the blood by hyperuricemia, with serum or plasma urate concentrations exceeding 6.8 mg/dL (approximately 400 micromol/L); this level of urate is the approximate limit of urate solubility . The ...

Synovial fluid analysis; Treatment of calcium pyrophosphate crystal deposition (CPPD) disease

¶ Synovial fluid analysis should include white cell count and differential, Gram stain and culture, and crystal search under compensating polarized light microscopy. Δ Refer to UpToDate topic review on septic arthritis or septic bursitis, depending upon the affected region.